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Henry Young
Guest
Henry E. Young, PhD
Mercer University School of Medicine
Director, Adult Stem Cell Research Laboratory
Law School 3rd Floor Medical Research Laboratory
1021 Georgia Ave., Macon, GA 31207
I have performed 30+ years of research in the area of adult-derived stem cells from 10 species of mammals, including humans. The majority of my studies have dealt with the discovery, isolation, cultivation, cloning from single cells, freezing, and characterization of germ layer lineage mesodermal stem cells [Young et al., Clonogenic analysis reveals reserve stem cells in postnatal mammals. I. Pluripotent mesenchymal stem cells. Anat. Rec. 263:350-360, 2001], pluripotent epiblast-like stem cells [Young et al., Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells. Anat. Rec. 277A:178-203, 2004], and totipotent blastomere-like stem cells [Young and Black, Adult-derived stem cells. Minerva Biotechnologica 17:55-63, 2005]. I named the stem cells based on their inherent differentiation potential rather than on their tissue of origin [Young and Black, 2005]. In all species examined to date, these particular adult-derived stem cells are predominantly sequestered in skeletal muscle in the quiescent state and mobilize into the peripheral vasculature after injury [Stout et al., Primitive stem cells reside in adult swine skeletal muscle and are mobilized into the peripheral blood following trauma. American Surgeon 73 (11):1106-1110, 2007]. Recently, we received FDA approval to perform autologous human transplants for somatic injuries / diseases, in Georgia. We need to show proof of concept with autologous transplants before the FDA will allow us to perform allogeneic transplants to correct genetic disorders. In six months or less (depending on availability of funds), I should have a GMP/GLP facility ready to perform autologous adult human stem cell transplants in Macon, Georgia, USA. Our only exclusion criteria for these studies are individuals having communicable diseases. We have noted that the stem cells normally circulate in an inactive state continuously throughout the peripheral blood. We can easily obtain the stem cells by venipuncture (blood draw) and have discovered methods to segregate the stem cells from the erythrocytes and leukocytes. Our next, and most crucial step, is stem cell activation ex vivo (outside the body) before introduction back into the individual (autologous transplant). The activation step is the key critical step for the process to work. Inactivated stem cells remain quiescent. On the other hand, activated stem cells have restored damaged tissues to their original histoarchitecture (in animals) [Young et al., Adult reserve stem cells and their potential for tissue engineering. Cell Biochem Biophys, 40(1):1-80, 2004; Young et al., Adult-derived stem cells and their potential for tissue repair and molecular medicine. J Cell Molec Med 9:753-769, 2005]. Moreover, in our studies since the stem cells are autologous there is no need for immunosuppressant therapy, with its associated morbidity and mortality.
Thank you for your interest,
Dr. Young
Henry E. Young, Ph.D.
Professor of Anatomy, Division of Basic Medical Sciences
Professor, Department of Pediatrics,
Professor, Department of Obstetrics & Gynecology
Director of Embryology,
Director of Gross Anatomy,
Director of Gross Anatomical Dissection,
Director of Embryology, Histology, and Gross Anatomical Dissection
for Certified Registered Nurse Anesthesiologists
Mercer University School of Medicine
Director, Adult Stem Cell Research Laboratory
Law School 3rd Floor Medical Research Laboratory
1021 Georgia Ave., Macon, GA 31207
Mercer University School of Medicine
Director, Adult Stem Cell Research Laboratory
Law School 3rd Floor Medical Research Laboratory
1021 Georgia Ave., Macon, GA 31207
I have performed 30+ years of research in the area of adult-derived stem cells from 10 species of mammals, including humans. The majority of my studies have dealt with the discovery, isolation, cultivation, cloning from single cells, freezing, and characterization of germ layer lineage mesodermal stem cells [Young et al., Clonogenic analysis reveals reserve stem cells in postnatal mammals. I. Pluripotent mesenchymal stem cells. Anat. Rec. 263:350-360, 2001], pluripotent epiblast-like stem cells [Young et al., Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells. Anat. Rec. 277A:178-203, 2004], and totipotent blastomere-like stem cells [Young and Black, Adult-derived stem cells. Minerva Biotechnologica 17:55-63, 2005]. I named the stem cells based on their inherent differentiation potential rather than on their tissue of origin [Young and Black, 2005]. In all species examined to date, these particular adult-derived stem cells are predominantly sequestered in skeletal muscle in the quiescent state and mobilize into the peripheral vasculature after injury [Stout et al., Primitive stem cells reside in adult swine skeletal muscle and are mobilized into the peripheral blood following trauma. American Surgeon 73 (11):1106-1110, 2007]. Recently, we received FDA approval to perform autologous human transplants for somatic injuries / diseases, in Georgia. We need to show proof of concept with autologous transplants before the FDA will allow us to perform allogeneic transplants to correct genetic disorders. In six months or less (depending on availability of funds), I should have a GMP/GLP facility ready to perform autologous adult human stem cell transplants in Macon, Georgia, USA. Our only exclusion criteria for these studies are individuals having communicable diseases. We have noted that the stem cells normally circulate in an inactive state continuously throughout the peripheral blood. We can easily obtain the stem cells by venipuncture (blood draw) and have discovered methods to segregate the stem cells from the erythrocytes and leukocytes. Our next, and most crucial step, is stem cell activation ex vivo (outside the body) before introduction back into the individual (autologous transplant). The activation step is the key critical step for the process to work. Inactivated stem cells remain quiescent. On the other hand, activated stem cells have restored damaged tissues to their original histoarchitecture (in animals) [Young et al., Adult reserve stem cells and their potential for tissue engineering. Cell Biochem Biophys, 40(1):1-80, 2004; Young et al., Adult-derived stem cells and their potential for tissue repair and molecular medicine. J Cell Molec Med 9:753-769, 2005]. Moreover, in our studies since the stem cells are autologous there is no need for immunosuppressant therapy, with its associated morbidity and mortality.
Thank you for your interest,
Dr. Young
Henry E. Young, Ph.D.
Professor of Anatomy, Division of Basic Medical Sciences
Professor, Department of Pediatrics,
Professor, Department of Obstetrics & Gynecology
Director of Embryology,
Director of Gross Anatomy,
Director of Gross Anatomical Dissection,
Director of Embryology, Histology, and Gross Anatomical Dissection
for Certified Registered Nurse Anesthesiologists
Mercer University School of Medicine
Director, Adult Stem Cell Research Laboratory
Law School 3rd Floor Medical Research Laboratory
1021 Georgia Ave., Macon, GA 31207
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