Click for full study:
https://www.frontiersin.org/articles/10.3389/fphar.2019.00700/full
Conclusion
UA could alleviate CSE-induced emphysema and airway remodeling, a process involving all three UPR pathways. The process also involved suppression of ERS-associated apoptosis, attenuation of intrinsic and extrinsic apoptosis pathways, and down-regulation of p-Smad2/3.
https://www.frontiersin.org/articles/10.3389/fphar.2019.00700/full
Conclusion
UA could alleviate CSE-induced emphysema and airway remodeling, a process involving all three UPR pathways. The process also involved suppression of ERS-associated apoptosis, attenuation of intrinsic and extrinsic apoptosis pathways, and down-regulation of p-Smad2/3.