Reports on stem cell research findings from National Cheng-Kung University, Institute of Basic Medical Science provide new insights
NewsRx.com
12-05-08
New investigation results, 'Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice,' are detailed in a study published in Journal of Applied Physiology. According to a study from Tainan, Taiwan, "Aging is an important determinant of adult hippocampal neurogenesis as the proliferation of neural stem/precursor cells (NSCs) declines dramatically before middle age. Contrary to this, physical exercise is known to promote adult hippocampal neurogenesis."
"The objective of this study is to investigate the effects of mandatory treadmill running (TR) on neurogenesis, including 1) NSCs proliferation, 2) neurite outgrowth of neuronal progenitor cells, and 3) the survival of newborn neurons in dentate area of middle-aged animals. Compared with 3-mo-old mice, numbers of mitotic cells and neuronal progenitor cells decreased dramatically by middle age and remained at low levels after middle age. Five weeks of TR not only increased NSC proliferation and the number of immature neurons but also promoted the maturation and survival of immature neurons in middle-aged mice. The neurogenic and neurotrophic effects of TR were not due to the reduction of the age-related elevation of serum corticosterone. Significantly, 5 wk of TR restored the age-dependent decline of brain-derived neurotrophic factor and its receptor, TrkB, which are known to promote neuronal differentiation and survival," wrote C.W. Wu and colleagues, National Cheng-Kung University, Institute of Basic Medical Science (see also Stem Cell Research).
The researchers concluded: "Taken together, mandatory running exercise alters the brain chemistries of middle-aged animals toward an environment that is favorable to NSC proliferation, survival, and maturation."
Wu and colleagues published the results of their research in the Journal of Applied Physiology (Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. Journal of Applied Physiology, 2008;105(5):1585-94).
For additional information, contact C.W. Wu, Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan.
The publisher of the Journal of Applied Physiology can be contacted at: American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA.
Keywords: Taiwan, Tainan, Applied Physiology, Neurogenesis, Progenitor Cell, Stem Cell Research.
This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2008, Stem Cell Week via NewsRx.com.
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .
NewsRx.com
12-05-08
New investigation results, 'Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice,' are detailed in a study published in Journal of Applied Physiology. According to a study from Tainan, Taiwan, "Aging is an important determinant of adult hippocampal neurogenesis as the proliferation of neural stem/precursor cells (NSCs) declines dramatically before middle age. Contrary to this, physical exercise is known to promote adult hippocampal neurogenesis."
"The objective of this study is to investigate the effects of mandatory treadmill running (TR) on neurogenesis, including 1) NSCs proliferation, 2) neurite outgrowth of neuronal progenitor cells, and 3) the survival of newborn neurons in dentate area of middle-aged animals. Compared with 3-mo-old mice, numbers of mitotic cells and neuronal progenitor cells decreased dramatically by middle age and remained at low levels after middle age. Five weeks of TR not only increased NSC proliferation and the number of immature neurons but also promoted the maturation and survival of immature neurons in middle-aged mice. The neurogenic and neurotrophic effects of TR were not due to the reduction of the age-related elevation of serum corticosterone. Significantly, 5 wk of TR restored the age-dependent decline of brain-derived neurotrophic factor and its receptor, TrkB, which are known to promote neuronal differentiation and survival," wrote C.W. Wu and colleagues, National Cheng-Kung University, Institute of Basic Medical Science (see also Stem Cell Research).
The researchers concluded: "Taken together, mandatory running exercise alters the brain chemistries of middle-aged animals toward an environment that is favorable to NSC proliferation, survival, and maturation."
Wu and colleagues published the results of their research in the Journal of Applied Physiology (Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. Journal of Applied Physiology, 2008;105(5):1585-94).
For additional information, contact C.W. Wu, Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan.
The publisher of the Journal of Applied Physiology can be contacted at: American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA.
Keywords: Taiwan, Tainan, Applied Physiology, Neurogenesis, Progenitor Cell, Stem Cell Research.
This article was prepared by Stem Cell Week editors from staff and other reports. Copyright 2008, Stem Cell Week via NewsRx.com.
To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .