Duke Researchers Learn How Lung Fibrosis Begins And Could Be Treated

danny

New member
ScienceDaily (June 27, 2011) — An invasive cell that leads to fibrosis of the lungs may be stopped by cutting off its supply of sugar, according to researchers at Duke University Medical Center

Idiopathic pulmonary fibrosis (IPF), which affects about 100,000 people in the U.S. each year and leads to death within three years of diagnosis, has only one therapy in the U. S.: lung transplantation.

Duke researchers have found a possible new treatment by identifying a cell surface receptor on the invasive cells called myofibroblasts and an enzyme that produces a sugar the receptor recognizes.

Senior author Paul Noble, M.D., the Duke Division Chief of Pulmonary, Allergy, and Critical Care Medicine, and his team used a mouse model and later, human cells from IPF patients, to show that the invasive type of cell depends on both the enzyme that makes a sugar called hyaluronan and the cell receptor that recognizes hyaluronan, CD44.

"The animal model we used targeted excessive production of hyaluronan in the myofibroblasts," Noble said. "We found that these cells invaded and destroyed surrounding tissue matrix similar to the behavior of cancer cells during metastasis."

The study was published in the June 27 online edition of the Journal of Experimental Medicine.

The researchers reduced lung fibrosis in living mice by treating them with a blocking antibody against the CD44 receptor or stopping the production of the enzyme that produces hyaluronan. .

The invasiveness occurs when the myofibroblast produces excessive hyaluronan. Because the sugar is necessary for living (embryos without it don't develop), the sugar production cannot be completely blocked. Instead, the overproduction of the sugar must be stopped to keep the invasive cells from overtaking the spaces in the lung where vital gas exchange occurs.

The process of fibrosis in the lung is like a healing wound on skin, Noble said. The fibrotic cells clamp down, pull in the skin, and hold it together more tightly. In the lungs, this clamping down of small airways prevents essential respiration and leads to death due to irreversible loss of lung function.

An earlier paper Noble published in March in Science Translational Medicine showed that intracellular signaling proteins called beta-arrestins were necessary for fibroblasts to invade tissue. Mice with a targeted deletion in beta-arrestins didn't develop severe pulmonary fibrosis. He did this work with receptor-science pioneer Robert Lefkowitz, M.D., of Duke Departments of Medicine and Biochemistry.

The two studies, taken together, suggest several approaches to treating invasive fibrosis in the lungs, Noble said. They might specifically block hyaluronan production and the receptor for the sugar. Or they might block the invasion process by targeting beta-arrestins to prevent myofibroblasts from making contact with the matrix (noncellular part) of the lung.

Noble thinks looking at additional targets to block the invasion process might be the best approach of all. "If we can study human fibroblasts and also the transgenic mouse as a model system, we could find more clues to stop the cells from invading," he said. "Several drugs are already approved that may have these properties that we need."

Other authors include: Yuejuan Li, Dianhua Jiang, Jiurong Liang, Eric B. Meltzer and Alice Gray of the Duke Division Chief of Pulmonary, Allergy, and Critical Care Medicine; Riu Mirua and Yu Yamaguchi of the Sanford Children's Health Research Center, Burnham Institute for Medical Research, La Jolla, CA; and Lise Wogensen of the Research Laboratory for Biochemical Pathology, Aarhus University Hospital, Aarhus, Denmark.

Funding for the study came from NIH grants and the Drinkard Research Fund.
 

RichardN

New member
So which drugs are available that can do this? Give us the names so we can get our doctors to prescribe and possibly save our lives
 

barbara

Pioneer Founding member
Pirfenidone has been approved in Europe for IPF. You can get it by prescription in Canada.

I am not sure what the Duke study entailed, but very often, you can write the researcher who did the study and they will give you information. It doesn't sound like it was for any kind of drug. I would contact this doctor for more information. Ask him is he knows of any promising new drugs or clinical trials for IPF.

Senior author Paul Noble, M.D., the Duke Division Chief of Pulmonary, Allergy, and Critical Care Medicine

Division Chief, Pulmonary, Allergy, and Critical Care Medicine

Department / Division
Medicine / Pulmonary, Allergy, and Critical Care Medicine

Address
2079 MSRB II, 106 Research Drive
DUMC 103000
Durham, NC 27710

Appointment Telephone
919-668-7630

Office Telephone
919-681-5961

Fax Telephone
919-684-5389

Training
MD, New York University School of Medicine, 1984
Residency
Internal Medicine, UCSF Medical Center (California), 1984-1988
Fellowship
Pulmonology, University of Colorado Hospital, 1988-1991
Clinical Interests
Pulmonary, allergy, and critical care medicine
 

RichardN

New member
Thanks for the above info Barbara. I will contact the researcher and see if he will say what prescription drugs could be used to combat scarring. The article did state that there were possibly already approved drugs that could stop the process.
 

barbara

Pioneer Founding member
You might want to submit any questions you have to next month's Ask the Doctor host, Dr Paulo Macchiarini. One of his main interests is lung disease.
Questions can be sent via Private Message to me.
 
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