Being new to this forum and not being too sure whether there was a dedicated section to Brain Damage, I thought the best place to put this thread in was the general section.
I have found an article on the latest stemcell line and transplant invention to treat the following diseases and pathological conditions are examples of diseases or conditions which result in deficits which may be treated in accordance with the present invention: traumatic brain injury, stroke, perinatal ischaemia, including cerebral palsy, Alzheimer's, Pick's and related dementing neurodegenerative diseases, multiple sclerosis, multi-infarct dementia, Parkinson's and Parkinson's-type diseases, Huntington's disease, Korsakoff's disease and Creuzfeld-Jacob disease. Amnesia, particularly following transitory global ischaemia such as after cardiac arrest or coronary bypass surgery, may also be treated in accordance with the present invention.
This new invention being patented in the US for a UK based stemcell research company Reneuron states that "It has now been realised that pluripotent cells can successfully repair damage when administered into the side of the brain contra-lateral to that containing the site of damage."
The conclusions of this patented invention states that:
"The findings indicated that both sensorimotor and motor asymmetries were normalised in rats with grafts initially sited in the intact hemisphere. The evidence for recovery of sensorimotor and motor functions is robust, because improvements were seen over an extended time period. There was some evidence of grafted cells on the side of implantation, not only around the sites of injection, but also forming a ventral stream of migration through the striatum. Thus it may be premature to conclude that grafted cells exert functional effects only if they cross to the side of damage. They may also be involved in reorganisation of the intact hemisphere. This conclusion is supported by finding that cells implanted on the lesion side migrated to the intact contra-lateral side."
The patented invention details can be found at http://www.stemcellpatents.com/patents-show-1170 and follow the link saying "View this patent on the USPTO website"
Although this is not yet available, it is definitely a very encouraging development and has been patented in July. The encouraging bit here is that they are talking in terms of repair not ifs and buts.
Further to the above it is interesting to visit Reneurons' website which states that for stroke which after all results in brain damage similar to that caused by hypoxia, "We have filed our IND application to commence clinical trials with ReN001 in the US, and we hope to initiate a Phase 1 study in stroke patients as soon as possible." For more - http://www.reneuron.com/
My interest in the matter comes through my 18 month old son who has acquired brain injury since April this year. We have a website through which we hope to raise awareness and pressure for sustained and determined stem cell research.
http://www.freewebs.com/nathanellul/index.htm
I have found an article on the latest stemcell line and transplant invention to treat the following diseases and pathological conditions are examples of diseases or conditions which result in deficits which may be treated in accordance with the present invention: traumatic brain injury, stroke, perinatal ischaemia, including cerebral palsy, Alzheimer's, Pick's and related dementing neurodegenerative diseases, multiple sclerosis, multi-infarct dementia, Parkinson's and Parkinson's-type diseases, Huntington's disease, Korsakoff's disease and Creuzfeld-Jacob disease. Amnesia, particularly following transitory global ischaemia such as after cardiac arrest or coronary bypass surgery, may also be treated in accordance with the present invention.
This new invention being patented in the US for a UK based stemcell research company Reneuron states that "It has now been realised that pluripotent cells can successfully repair damage when administered into the side of the brain contra-lateral to that containing the site of damage."
The conclusions of this patented invention states that:
"The findings indicated that both sensorimotor and motor asymmetries were normalised in rats with grafts initially sited in the intact hemisphere. The evidence for recovery of sensorimotor and motor functions is robust, because improvements were seen over an extended time period. There was some evidence of grafted cells on the side of implantation, not only around the sites of injection, but also forming a ventral stream of migration through the striatum. Thus it may be premature to conclude that grafted cells exert functional effects only if they cross to the side of damage. They may also be involved in reorganisation of the intact hemisphere. This conclusion is supported by finding that cells implanted on the lesion side migrated to the intact contra-lateral side."
The patented invention details can be found at http://www.stemcellpatents.com/patents-show-1170 and follow the link saying "View this patent on the USPTO website"
Although this is not yet available, it is definitely a very encouraging development and has been patented in July. The encouraging bit here is that they are talking in terms of repair not ifs and buts.
Further to the above it is interesting to visit Reneurons' website which states that for stroke which after all results in brain damage similar to that caused by hypoxia, "We have filed our IND application to commence clinical trials with ReN001 in the US, and we hope to initiate a Phase 1 study in stroke patients as soon as possible." For more - http://www.reneuron.com/
My interest in the matter comes through my 18 month old son who has acquired brain injury since April this year. We have a website through which we hope to raise awareness and pressure for sustained and determined stem cell research.
http://www.freewebs.com/nathanellul/index.htm
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