I believe there was a previous discussion on CP and Vitamin D, but this is an actual study that has been published.
Journal of Cystic Fibrosis
Volume 9, Issue 2, Pages 143-149 (March 2010)
Transient effectiveness of vitamin D2 therapy in pediatric cystic fibrosis patients☆
Deanna M. Green, Amanda R. Leonard, Shruti M. Paranjape, Beryl J. Rosenstein, Pamela L. Zeitlin, Peter J. Mogayzel Jr.
Received 25 September 2009; received in revised form 4 January 2010; accepted 13 January 2010.
The effectiveness of current treatment recommendations for vitamin D insufficiency in children with CF is unknown. Therefore, we assessed the effectiveness of vitamin D2 50,000IU once daily for 28days for vitamin D insufficiency.
Retrospective chart review of pediatric CF patients from 2006?2008. Vitamin D2 50,000IU daily for 28days was given to patients with 25-OHD <30ng/mL and repeat 25-OHD levels were obtained after completion of therapy.
Results
One hundred forty-seven levels from 97 individuals were assessed. Success of treatment was 54% (n=80/147). Seventeen of 39 patients (43%) followed for an additional 6?18months were able to maintain levels of ≥30ng/mL.
Conclusions
Vitamin D2 50,000IU daily for 28days was effective in correcting vitamin D insufficiency in approximately 50% of subjects. However, almost half of successfully treated patients were unable to maintain normal 25-OHD levels >6months after completion of therapy, implying that this effect is transient.
Abbreviations: CF, cystic fibrosis, 25-OHD, 25-hydroxy-vitamin D, IU, international units, PTH, parathyroid hormone, FEV1, forced expiratory volume in 1s, BMI, body mass index, χ2, chi-square, 25-OHD2, 25-hydroxy-vitamin D2, 25-OHD3, 25-hydroxy-vitamin D3, UV, ultraviolet.
Journal of Cystic Fibrosis
Volume 9, Issue 2, Pages 143-149 (March 2010)
Transient effectiveness of vitamin D2 therapy in pediatric cystic fibrosis patients☆
Deanna M. Green, Amanda R. Leonard, Shruti M. Paranjape, Beryl J. Rosenstein, Pamela L. Zeitlin, Peter J. Mogayzel Jr.
Received 25 September 2009; received in revised form 4 January 2010; accepted 13 January 2010.
The effectiveness of current treatment recommendations for vitamin D insufficiency in children with CF is unknown. Therefore, we assessed the effectiveness of vitamin D2 50,000IU once daily for 28days for vitamin D insufficiency.
Retrospective chart review of pediatric CF patients from 2006?2008. Vitamin D2 50,000IU daily for 28days was given to patients with 25-OHD <30ng/mL and repeat 25-OHD levels were obtained after completion of therapy.
Results
One hundred forty-seven levels from 97 individuals were assessed. Success of treatment was 54% (n=80/147). Seventeen of 39 patients (43%) followed for an additional 6?18months were able to maintain levels of ≥30ng/mL.
Conclusions
Vitamin D2 50,000IU daily for 28days was effective in correcting vitamin D insufficiency in approximately 50% of subjects. However, almost half of successfully treated patients were unable to maintain normal 25-OHD levels >6months after completion of therapy, implying that this effect is transient.
Abbreviations: CF, cystic fibrosis, 25-OHD, 25-hydroxy-vitamin D, IU, international units, PTH, parathyroid hormone, FEV1, forced expiratory volume in 1s, BMI, body mass index, χ2, chi-square, 25-OHD2, 25-hydroxy-vitamin D2, 25-OHD3, 25-hydroxy-vitamin D3, UV, ultraviolet.