Stem Cells Speed Growth Of Healthy Liver http://www.sciencedaily.com/releases/2007/03/070327094518.htm
Stem Cells Speed Growth Of Healthy Liver Tissue
- Thread starter zar
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stems/liver cancer
Patients treated for advanced liver cancer have grown new liver cells after being injected with stem cells taken from their hips.
Six out of eight patients are still alive two years later with fully functioning livers. The treatment, given in Germany, brings hope for liver patients.
Surgeons at the University of Dusseldorf took bone marrow stem cells from the hips of patients with advanced liver cancer and injected then into the healthy parts of the liver. The organ is capable of regeneration but the patients had only 20 per cent of healthy liver left, not enough for surgery.
The surgeons diverted blood supplying the diseased part of the liver to the remaining healthy part which accelerated the growth of new liver cells. At the same time they injected stem cells from the hips into the blood supplying the healthy part of the liver.
They say in the journal Radiology that after a few weeks enough liver tissue had grown for surgeons to remove the cancers
Patients treated for advanced liver cancer have grown new liver cells after being injected with stem cells taken from their hips.
Six out of eight patients are still alive two years later with fully functioning livers. The treatment, given in Germany, brings hope for liver patients.
Surgeons at the University of Dusseldorf took bone marrow stem cells from the hips of patients with advanced liver cancer and injected then into the healthy parts of the liver. The organ is capable of regeneration but the patients had only 20 per cent of healthy liver left, not enough for surgery.
The surgeons diverted blood supplying the diseased part of the liver to the remaining healthy part which accelerated the growth of new liver cells. At the same time they injected stem cells from the hips into the blood supplying the healthy part of the liver.
They say in the journal Radiology that after a few weeks enough liver tissue had grown for surgeons to remove the cancers
stems/liver cancer
Patients treated for advanced liver cancer have grown new liver cells after being injected with stem cells taken from their hips.
Six out of eight patients are still alive two years later with fully functioning livers. The treatment, given in Germany, brings hope for liver patients.
Surgeons at the University of Dusseldorf took bone marrow stem cells from the hips of patients with advanced liver cancer and injected then into the healthy parts of the liver. The organ is capable of regeneration but the patients had only 20 per cent of healthy liver left, not enough for surgery.
The surgeons diverted blood supplying the diseased part of the liver to the remaining healthy part which accelerated the growth of new liver cells. At the same time they injected stem cells from the hips into the blood supplying the healthy part of the liver.
http://www.stemcells.co.in/
They say in the journal Radiology that after a few weeks enough liver tissue had grown for surgeons to remove the cancers
Patients treated for advanced liver cancer have grown new liver cells after being injected with stem cells taken from their hips.
Six out of eight patients are still alive two years later with fully functioning livers. The treatment, given in Germany, brings hope for liver patients.
Surgeons at the University of Dusseldorf took bone marrow stem cells from the hips of patients with advanced liver cancer and injected then into the healthy parts of the liver. The organ is capable of regeneration but the patients had only 20 per cent of healthy liver left, not enough for surgery.
The surgeons diverted blood supplying the diseased part of the liver to the remaining healthy part which accelerated the growth of new liver cells. At the same time they injected stem cells from the hips into the blood supplying the healthy part of the liver.
http://www.stemcells.co.in/
They say in the journal Radiology that after a few weeks enough liver tissue had grown for surgeons to remove the cancers
cellmedicine
New member
bone marrow stem cells for liver failure
There is also a paper with 9 end stage patients who recieved their own bone marrow and their enzymes improved as well as Child Pugh scores improved
Stem Cells. 2006 Oct;24(10):2292-8. Epub 2006 Jun 15. Links
Comment in:
Stem Cells. 2007 Sep;25(9):2383-4.
Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy.Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, Okita K, Sakaida I.
Department of Molecular Science & Applied Medicine (Gastroenterology & Hepatology), Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan. terais@yamaguchi-u.ac.jp
We here report nine liver cirrhosis (LC) patients that underwent autologous bone marrow cell infusion (ABMI) from the peripheral vein. Subjects were patients with LC with total bilirubin of less than 3.0 mg/dl, platelet count of more than 5 (10(10)/l), and no viable hepatocellular carcinoma on diagnostic imaging. Autologous bone marrow (BM; 400 ml) was isolated from the ilium under general anesthesia. Mononuclear cells (MNCs) were separated by cell washing and were infused via the peripheral vein. MNC characteristics were confirmed by fluorescence-activated cell sorting analysis (CD34, CD45, and c-kit). After ABMI therapy, liver function was monitored by blood examination for 24 weeks. From 400 ml of BM, we obtained 7.81 +/- 0.98 x 10(9) MNCs. After washing, 5.20 +/- 0.63 x 10(9) MNCs were infused into patients with LC. Significant improvements in serum albumin levels and total protein were observed at 24 weeks after ABMI therapy (p < .05). Significantly improved Child-Pugh scores were seen at 4 and 24 weeks (p < .05). alpha-Fetoprotein and proliferating cell nuclear antigen (PCNA) expression in liver biopsy tissue was significantly elevated after ABMI therapy (p < .05). No major adverse effects were noted. In conclusion, ABMI therapy should be considered as a novel treatment for patients with decompensated LC.
There is also a paper with 9 end stage patients who recieved their own bone marrow and their enzymes improved as well as Child Pugh scores improved
Stem Cells. 2006 Oct;24(10):2292-8. Epub 2006 Jun 15. Links
Comment in:
Stem Cells. 2007 Sep;25(9):2383-4.
Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy.Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, Okita K, Sakaida I.
Department of Molecular Science & Applied Medicine (Gastroenterology & Hepatology), Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan. terais@yamaguchi-u.ac.jp
We here report nine liver cirrhosis (LC) patients that underwent autologous bone marrow cell infusion (ABMI) from the peripheral vein. Subjects were patients with LC with total bilirubin of less than 3.0 mg/dl, platelet count of more than 5 (10(10)/l), and no viable hepatocellular carcinoma on diagnostic imaging. Autologous bone marrow (BM; 400 ml) was isolated from the ilium under general anesthesia. Mononuclear cells (MNCs) were separated by cell washing and were infused via the peripheral vein. MNC characteristics were confirmed by fluorescence-activated cell sorting analysis (CD34, CD45, and c-kit). After ABMI therapy, liver function was monitored by blood examination for 24 weeks. From 400 ml of BM, we obtained 7.81 +/- 0.98 x 10(9) MNCs. After washing, 5.20 +/- 0.63 x 10(9) MNCs were infused into patients with LC. Significant improvements in serum albumin levels and total protein were observed at 24 weeks after ABMI therapy (p < .05). Significantly improved Child-Pugh scores were seen at 4 and 24 weeks (p < .05). alpha-Fetoprotein and proliferating cell nuclear antigen (PCNA) expression in liver biopsy tissue was significantly elevated after ABMI therapy (p < .05). No major adverse effects were noted. In conclusion, ABMI therapy should be considered as a novel treatment for patients with decompensated LC.