This looks like a very significant advance!
http://www.medicalnewstoday.com/articles/290655.php?tw
A short excerpt:
New class of drugs take 'big first step' toward slowing the aging process
The results of a new study have pushed researchers one step closer to developing drugs that slow the human aging process. Scientists from The Scripps Research Institute in Jupiter, FL, the Mayo Clinic in Rochester, MN, and colleagues have identified a new class of drugs that dramatically improved cardiac function, reduced symptoms of frailty and prolonged the healthy lifespan of mice.
A single dose produced significant anti-aging effects
From testing 46 drugs on human senescent cells in culture, the researchers identified two that showed promise: a cancer drug called dasatinib (brand name Sprycel), and an antihistamine and anti-inflammatory supplement called quercetin.
Used together, the researchers found the compounds effectively induced apoptosis in senescent cells.
On testing a combination of the two drugs in mouse models, the team found they significantly improved cardiovascular function, boosted exercised endurance, reduced osteoporosis and frailty and dramatically extended the animals' lifespan. "Remarkably, in some cases, these drugs did so with only a single course of treatment," says Dr. Niedernhofer.
In detail, a single dose of senolytics improved the cardiovascular function of older mice within 5 days, while one dose was found to significantly boost exercise endurance in weak mice that had been exposed to radiation therapy. The team says these effects lasted for at least 7 months.
Among mice with accelerated aging, the researchers found regular administration of the senolytics delayed age-related symptoms, spine degeneration and osteoporosis, and increased their healthy lifespan.
http://www.medicalnewstoday.com/articles/290655.php?tw
A short excerpt:
New class of drugs take 'big first step' toward slowing the aging process
The results of a new study have pushed researchers one step closer to developing drugs that slow the human aging process. Scientists from The Scripps Research Institute in Jupiter, FL, the Mayo Clinic in Rochester, MN, and colleagues have identified a new class of drugs that dramatically improved cardiac function, reduced symptoms of frailty and prolonged the healthy lifespan of mice.
A single dose produced significant anti-aging effects
From testing 46 drugs on human senescent cells in culture, the researchers identified two that showed promise: a cancer drug called dasatinib (brand name Sprycel), and an antihistamine and anti-inflammatory supplement called quercetin.
Used together, the researchers found the compounds effectively induced apoptosis in senescent cells.
On testing a combination of the two drugs in mouse models, the team found they significantly improved cardiovascular function, boosted exercised endurance, reduced osteoporosis and frailty and dramatically extended the animals' lifespan. "Remarkably, in some cases, these drugs did so with only a single course of treatment," says Dr. Niedernhofer.
In detail, a single dose of senolytics improved the cardiovascular function of older mice within 5 days, while one dose was found to significantly boost exercise endurance in weak mice that had been exposed to radiation therapy. The team says these effects lasted for at least 7 months.
Among mice with accelerated aging, the researchers found regular administration of the senolytics delayed age-related symptoms, spine degeneration and osteoporosis, and increased their healthy lifespan.
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