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Given the propensity of stem cells derived from Wharton's Jelly to become neurons and neurospheres. This article is more proof that these stem cells might even be better than autologous stem cell therapies for neurological problems.
Dave Snow
http://www.springerlink.com/content/p3382h524w863v62/
Human Wharton?s Jelly Stem Cells Have Unique Transcriptome Profiles Compared to Human Embryonic Stem Cells and Other Mesenchymal Stem Cells
Chui-Yee Fong, Li-Ling Chak, Arijit Biswas, Jee-Hian Tan, Kalamegam Gauthaman, Woon-Khiong Chan and Ariff Bongso
Download PDF (977.1 KB)View HTMLPermissions & ReprintsRelatedJournalView Related Documents
full accessJournal Article
Effectiveness of protocol for the isolation of Wharton?s Jelly stem cells in large-scale applications
Anastasia Petsa, Sofia Gargani, Antigonos Felesakis, Nikolaos Grigoriadis and Ioannis Grigoriadis
In Vitro Cellular & Developmental Biology - Animal, 2009, Volume 45, Number 10, Pages 573-576
Download PDF (184.8 KB)View HTML
Journal ArticleEffectiveness of protocol for the isolation of Wharton?s Jelly stem cells in large-scale applicationsAnastasia Petsa
no accessJournal Article
Fetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansion
Chris H. Jo, Ok-Su Kim, Eun-Young Park, Byoung Jae Kim and Ji-Ho Lee, et al.
Cell and Tissue Research, 2008, Volume 334, Number 3, Pages 423-433
Download PDF (676.6 KB)View HTML
Journal ArticleFetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansionChris H. Jo
no accessBook Chapter
Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications
Pierre Moretti, Tim Hatlapatka, Dana Marten, Antonina Lavrentieva and Ingrida Majore, et al.
Advances in Biochemical Engineering/Biotechnology, 2010, [Without Title], Pages 1-26
Download PDF (673.2 KB)View HTMLLook Inside
Book ChapterMesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering ApplicationsPierre Moretti
full accessJournal Article
Simultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cord
Sachin S. Kadam, Shubha Tiwari and Ramesh R. Bhonde
In Vitro Cellular & Developmental Biology - Animal, 2009, Volume 45, Numbers 1-2, Pages 23-27
Download PDF (426.6 KB)View HTML
Journal ArticleSimultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cordSachin S. Kadam
no accessJournal Article
Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton?s jelly explants of human umbilical cord
Ikuo Ishige, Tokiko Nagamura-Inoue, Masaki J. Honda, Ratanakanit Harnprasopwat and Michiko Kido, et al.
International Journal of Hematology, 2009, Volume 90, Number 2, Pages 261-269
Download PDF (456.9 KB)View HTML
Journal ArticleComparison of mesenchymal stem cells derived from arterial, venous, and Wharton?s jelly explants of human umbilical cordIkuo Ishige
no accessBook Chapter
Umbilical Cord Stem Cells
Kathy E. Mitchell
Contemporary Endocrinology, 2005, Stem Cells in Endocrinology, Part I, Pages 49-65
Download PDF (428.9 KB)Look Inside
Book ChapterUmbilical Cord Stem CellsKathy E. Mitchell
no accessJournal Article
Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers
Giampiero La Rocca, Rita Anzalone, Simona Corrao, Francesca Magno and Tiziana Loria, et al.
Histochemistry and Cell Biology, 2009, Volume 131, Number 2, Pages 267-282
Download PDF (1.0 MB)View HTML
Journal ArticleIsolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markersGiampiero La Rocca
full accessJournal Article
Stem Cells in Amniotic Fluid as New Tools to Study Human Genetic Diseases
Nicol Siegel, Margit Rosner, Michaela Hanneder, Alessandro Valli and Markus Hengstschl?ger
Stem Cell Reviews and Reports, 2007, Volume 3, Number 4, Pages 256-264
Download PDF (152.2 KB)View HTML
Journal ArticleStem Cells in Amniotic Fluid as New Tools to Study Human Genetic DiseasesNicol Siegel
no accessJournal Article
Stem and progenitor cells in human umbilical cord blood
Myoung Woo Lee, In Keun Jang, Keon Hee Yoo, Ki Woong Sung and Hong Hoe Koo
International Journal of Hematology, 2010, Volume 92, Number 1, Pages 45-51
Download PDF (195.0 KB)View HTML
Journal ArticleStem and progenitor cells in human umbilical cord bloodMyoung Woo Lee
no accessJournal Article
Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats
Huiling Cao, Hui Qian, Wenrong Xu, Wei Zhu and Xu Zhang, et al.
Biotechnology Letters, 2010, Volume 32, Number 5, Pages 725-732
Download PDF (454.4 KB)View HTML
Journal ArticleMesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in ratsHuiling Cao
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Supplementals (1)References (86)Export CitationAboutAbstract
The human umbilical cord that originates from the embryo is an extra-embryonic membrane and the Wharton?s jelly within it is a rich source of stem cells (hWJSCs). It is not definitely known whether these cells behave as human embryonic stem cells (hESCs), human mesenchymal stem cells (hMSC) or both. They have the unique properties of high proliferation rates, wide multipotency, hypoimmunogenicity, do not induce teratomas and have anticancer properties. These advantages are important considerations for their use in cell based therapies and treatment of cancers. In a search for properties that confer these advantages we compared a detailed transcriptome profiling of hWJSCs using DNA microarrays with that of a panel of known hESCs, hMSCs and stromal cells. hWJSCs expressed low levels of the pluripotent embryonic stem cell markers including POUF1, NANOG, SOX2 and LIN28, thus explaining why they do not produce teratomas. Several cytokines were significantly upregulated in hWJSCs including IL12A which is associated with the induction of apoptosis, thus explaining their anticancer properties. When GO Biological Process analysis was compared between the various stem cell types, hWJSCs showed an increased expression of genes associated with the immune system, chemotaxis and cell death. The ability to modulate immune responses makes hWJSCs an important compatible stem cell source for transplantation therapy in allogeneic settings without immunorejection. The data in the present study which is the first detailed report on hWJSC transcriptomes provide a foundation for future functional studies where the exact mechanisms of these unique properties of hWJSCs can be confirmed.
Dave Snow
http://www.springerlink.com/content/p3382h524w863v62/
Human Wharton?s Jelly Stem Cells Have Unique Transcriptome Profiles Compared to Human Embryonic Stem Cells and Other Mesenchymal Stem Cells
Chui-Yee Fong, Li-Ling Chak, Arijit Biswas, Jee-Hian Tan, Kalamegam Gauthaman, Woon-Khiong Chan and Ariff Bongso
Download PDF (977.1 KB)View HTMLPermissions & ReprintsRelatedJournalView Related Documents
full accessJournal Article
Effectiveness of protocol for the isolation of Wharton?s Jelly stem cells in large-scale applications
Anastasia Petsa, Sofia Gargani, Antigonos Felesakis, Nikolaos Grigoriadis and Ioannis Grigoriadis
In Vitro Cellular & Developmental Biology - Animal, 2009, Volume 45, Number 10, Pages 573-576
Download PDF (184.8 KB)View HTML
Journal ArticleEffectiveness of protocol for the isolation of Wharton?s Jelly stem cells in large-scale applicationsAnastasia Petsa
no accessJournal Article
Fetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansion
Chris H. Jo, Ok-Su Kim, Eun-Young Park, Byoung Jae Kim and Ji-Ho Lee, et al.
Cell and Tissue Research, 2008, Volume 334, Number 3, Pages 423-433
Download PDF (676.6 KB)View HTML
Journal ArticleFetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansionChris H. Jo
no accessBook Chapter
Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications
Pierre Moretti, Tim Hatlapatka, Dana Marten, Antonina Lavrentieva and Ingrida Majore, et al.
Advances in Biochemical Engineering/Biotechnology, 2010, [Without Title], Pages 1-26
Download PDF (673.2 KB)View HTMLLook Inside
Book ChapterMesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering ApplicationsPierre Moretti
full accessJournal Article
Simultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cord
Sachin S. Kadam, Shubha Tiwari and Ramesh R. Bhonde
In Vitro Cellular & Developmental Biology - Animal, 2009, Volume 45, Numbers 1-2, Pages 23-27
Download PDF (426.6 KB)View HTML
Journal ArticleSimultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cordSachin S. Kadam
no accessJournal Article
Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton?s jelly explants of human umbilical cord
Ikuo Ishige, Tokiko Nagamura-Inoue, Masaki J. Honda, Ratanakanit Harnprasopwat and Michiko Kido, et al.
International Journal of Hematology, 2009, Volume 90, Number 2, Pages 261-269
Download PDF (456.9 KB)View HTML
Journal ArticleComparison of mesenchymal stem cells derived from arterial, venous, and Wharton?s jelly explants of human umbilical cordIkuo Ishige
no accessBook Chapter
Umbilical Cord Stem Cells
Kathy E. Mitchell
Contemporary Endocrinology, 2005, Stem Cells in Endocrinology, Part I, Pages 49-65
Download PDF (428.9 KB)Look Inside
Book ChapterUmbilical Cord Stem CellsKathy E. Mitchell
no accessJournal Article
Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers
Giampiero La Rocca, Rita Anzalone, Simona Corrao, Francesca Magno and Tiziana Loria, et al.
Histochemistry and Cell Biology, 2009, Volume 131, Number 2, Pages 267-282
Download PDF (1.0 MB)View HTML
Journal ArticleIsolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markersGiampiero La Rocca
full accessJournal Article
Stem Cells in Amniotic Fluid as New Tools to Study Human Genetic Diseases
Nicol Siegel, Margit Rosner, Michaela Hanneder, Alessandro Valli and Markus Hengstschl?ger
Stem Cell Reviews and Reports, 2007, Volume 3, Number 4, Pages 256-264
Download PDF (152.2 KB)View HTML
Journal ArticleStem Cells in Amniotic Fluid as New Tools to Study Human Genetic DiseasesNicol Siegel
no accessJournal Article
Stem and progenitor cells in human umbilical cord blood
Myoung Woo Lee, In Keun Jang, Keon Hee Yoo, Ki Woong Sung and Hong Hoe Koo
International Journal of Hematology, 2010, Volume 92, Number 1, Pages 45-51
Download PDF (195.0 KB)View HTML
Journal ArticleStem and progenitor cells in human umbilical cord bloodMyoung Woo Lee
no accessJournal Article
Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats
Huiling Cao, Hui Qian, Wenrong Xu, Wei Zhu and Xu Zhang, et al.
Biotechnology Letters, 2010, Volume 32, Number 5, Pages 725-732
Download PDF (454.4 KB)View HTML
Journal ArticleMesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in ratsHuiling Cao
Scroll upScroll down
Supplementals (1)References (86)Export CitationAboutAbstract
The human umbilical cord that originates from the embryo is an extra-embryonic membrane and the Wharton?s jelly within it is a rich source of stem cells (hWJSCs). It is not definitely known whether these cells behave as human embryonic stem cells (hESCs), human mesenchymal stem cells (hMSC) or both. They have the unique properties of high proliferation rates, wide multipotency, hypoimmunogenicity, do not induce teratomas and have anticancer properties. These advantages are important considerations for their use in cell based therapies and treatment of cancers. In a search for properties that confer these advantages we compared a detailed transcriptome profiling of hWJSCs using DNA microarrays with that of a panel of known hESCs, hMSCs and stromal cells. hWJSCs expressed low levels of the pluripotent embryonic stem cell markers including POUF1, NANOG, SOX2 and LIN28, thus explaining why they do not produce teratomas. Several cytokines were significantly upregulated in hWJSCs including IL12A which is associated with the induction of apoptosis, thus explaining their anticancer properties. When GO Biological Process analysis was compared between the various stem cell types, hWJSCs showed an increased expression of genes associated with the immune system, chemotaxis and cell death. The ability to modulate immune responses makes hWJSCs an important compatible stem cell source for transplantation therapy in allogeneic settings without immunorejection. The data in the present study which is the first detailed report on hWJSC transcriptomes provide a foundation for future functional studies where the exact mechanisms of these unique properties of hWJSCs can be confirmed.