STEMCELL Technologies Applauds Feeder-Free Derivation of Human Induced Pluripotent Stem Cells
Mon Sep 14, 2009 1:26pm EDT
VANCOUVER--(Business Wire)--
In a landmark paper, researchers at Stanford University have described a new way
to derive human induced pluripotent stem cells (iPSCs) without the use of
contaminating mouse feeder cells. Using adipose cells as the starting cell
population and mTeSR1, a defined medium that allows the expansion of human
embryonic and induced pluripotent stem cells without the use of feeders, the
researchers were able to fully reprogram the cells to the pluripotent state.
iPSCs could potentially become the source of patient specific replacement cells,
but methods used to generate these cells to date have relied on the use of mouse
feeder cells which make the cells unsuitable for clinical use. "The fact that
adipose cells can now be reprogrammed without the use of contaminating feeder
cells means we are one step closer to being able to use these cells in the
clinic," said Dr. Joseph Wu, Assistant Professor of Medicine and Radiology at
Stanford University and senior author on the publication.
"mTeSR1 is proving to be a very versatile tool for working with iPSCs," said Dr.
Clive Glover, Senior Product Manager at STEMCELL Technologies. "Previously, it
has been shown that iPSCs can be expanded routinely with mTeSR1, but this study
suggests that mTeSR1 can be used all the way from initial derivation through to
expansion."
mTeSR1 is a fully defined medium and is the most widely used feeder-independent
method for culturing human pluripotent stem cells, with citations in more than
25 publications.
http://www.reuters.com/article/pressRelease/idUS155006+14-Sep-2009+BW20090914
Mon Sep 14, 2009 1:26pm EDT
VANCOUVER--(Business Wire)--
In a landmark paper, researchers at Stanford University have described a new way
to derive human induced pluripotent stem cells (iPSCs) without the use of
contaminating mouse feeder cells. Using adipose cells as the starting cell
population and mTeSR1, a defined medium that allows the expansion of human
embryonic and induced pluripotent stem cells without the use of feeders, the
researchers were able to fully reprogram the cells to the pluripotent state.
iPSCs could potentially become the source of patient specific replacement cells,
but methods used to generate these cells to date have relied on the use of mouse
feeder cells which make the cells unsuitable for clinical use. "The fact that
adipose cells can now be reprogrammed without the use of contaminating feeder
cells means we are one step closer to being able to use these cells in the
clinic," said Dr. Joseph Wu, Assistant Professor of Medicine and Radiology at
Stanford University and senior author on the publication.
"mTeSR1 is proving to be a very versatile tool for working with iPSCs," said Dr.
Clive Glover, Senior Product Manager at STEMCELL Technologies. "Previously, it
has been shown that iPSCs can be expanded routinely with mTeSR1, but this study
suggests that mTeSR1 can be used all the way from initial derivation through to
expansion."
mTeSR1 is a fully defined medium and is the most widely used feeder-independent
method for culturing human pluripotent stem cells, with citations in more than
25 publications.
http://www.reuters.com/article/pressRelease/idUS155006+14-Sep-2009+BW20090914