The Japan News
The Yomiuri Shimbun

A team of Kyoto University researchers has announced that it developed a method to generate strong hyaline cartilage from induced pluripotent stem cells.

The team, led by Prof. Noriyuki Tsumaki of the university’s Center for iPS Cell Research and Application, transplanted iPS-derived particles into a 30-kilogram mini-pig and found positive signs for integration into native cartilage.

The findings were published on Feb. 26 in the scientific magazine “Stem Cell Reports.”

The team aims to conduct clinical research for this regenerative medical technique in four years with patients who suffered damaged cartilage, such as those who have injured knee joints in sports.

Currently, a common technique for cartilage regeneration to treat defective cartilage requires cartilage to be taken from a biopsy to culture cartilage cells. The cultivated cells are then transplanted into the injured area.

According to its research release, the team cultured a significant number of human iPS cells in advance that helped synthesize cartilage cells effectively. After culturing the cartilage cells for several weeks, hyaline cartilage with healthy joint tissues was generated.Speech