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https://www.frontiersin.org/articles...019.00700/full

Conclusion
UA could alleviate CSE-induced emphysema and airway remodeling, a process involving all three UPR pathways. The process also involved suppression of ERS-associated apoptosis, attenuation of intrinsic and extrinsic apoptosis pathways, and down-regulation of p-Smad2/3.